Search results for "Acute Cardiovascular Problems"

showing 3 items of 3 documents

Anti-Hypotensive Treatment and Endothelin Blockade Synergistically Antagonize Exercise Fatigue in Rats under Simulated High Altitude

2013

Rapid ascent to high altitude causes illness and fatigue, and there is a demand for effective acute treatments to alleviate such effects. We hypothesized that increased oxygen delivery to the tissue using a combination of a hypertensive agent and an endothelin receptor A antagonist drugs would limit exercise-induced fatigue at simulated high altitude. Our data showed that the combination of 0.1 mg/kg ambrisentan with either 20 mg/kg ephedrine or 10 mg/kg methylphenidate significantly improved exercise duration in rats at simulated altitude of 4,267 m, whereas the individual compounds did not. In normoxic, anesthetized rats, ephedrine alone and in combination with ambrisentan increased heart…

Critical Care and Emergency MedicinePulmonologyPhysiologyAcclimatizationRespiratory Systemlcsh:MedicineAltitude SicknessPharmacologyCardiovascular PhysiologyDrug DiscoveryMedicine and Health SciencesDrug InteractionsSympathomimeticslcsh:ScienceFatigueAltitude sicknessEphedrineMammalsMultidisciplinaryPhenylpropionatesAltitudeDrug SynergismHematologyAnimal ModelsCell HypoxiaPyridazinesmedicine.anatomical_structureVertebratesBlood CirculationDrug Therapy CombinationAnatomymedicine.symptomEndothelin receptorPerfusionInjections IntraperitonealResearch Articlemedicine.drugDrug Research and DevelopmentAmbrisentanEndothelin A Receptor AntagonistsCardiologyEnvironmental and Occupational Lung DiseasesResearch and Analysis MethodsRodentsCardiovascular PharmacologyModel OrganismsHeart ratemedicineAnimalsRespiratory PhysiologySports and Exercise MedicinePharmacologyDose-Response Relationship Drugbusiness.industryAcute Cardiovascular Problemslcsh:ROrganismsHemodynamicsBiology and Life SciencesSkeletal muscleHypoxia (medical)medicine.diseaseRatsDisease Models AnimalBlood pressureMethylphenidateCardiovascular Anatomylcsh:QClinical MedicinebusinessPLoS ONE
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NT pro BNP plasma level and atrial volume are linked to the severity of liver cirrhosis.

2013

BACKGROUND AND AIMS: Plasma levels of NT-pro-BNP, a natriuretic peptide precursor, are raised in the presence of fluid retention of cardiac origin and can be used as markers of cardiac dysfunction. Recent studies showed high levels of NT pro BNP in patients with cirrhosis. We assessed NT pro-BNP and other parameters of cardiac dysfunction in patients with cirrhosis, with or without ascites, in order to determine whether the behaviour of NT pro BNP is linked to the stage of liver disease or to secondary cardiac dysfunction. METHODS: Fifty eight consecutive hospitalized patients mostly with viral or NAFLD-related cirrhosis were studied. All underwent abdominal ultrasound and upper GI endoscop…

Liver CirrhosisMaleCirrhosisAnatomy and Physiologylcsh:MedicineCardiovascularCardiovascular SystemLiver diseaseAscitesNatriuretic Peptide BrainNatriuretic peptidePathologylcsh:ScienceMultidisciplinaryLiver DiseasesMiddle AgedHypertensioncardiovascular systemCardiologyMedicineFemalemedicine.symptomhormones hormone substitutes and hormone antagonistscirculatory and respiratory physiologyResearch Articlemedicine.medical_specialtymedicine.drug_classGastroenterology and HepatologyCardiac dysfunctionDiagnostic MedicineInternal medicinemedicineHumanscardiovascular diseasesHeart Atriabusiness.industryAcute Cardiovascular Problemscirrhosislcsh:RCase-control studyPlasma levelsmedicine.diseasePeptide FragmentsEndocrinologyCase-Control Studieslcsh:QN terminal pro b type natriuretic peptidebusinesshuman activitiesBiomarkersGeneral Pathology
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High N-Terminal Pro-B-Type Natriuretic Peptide Levels Are Associated with Reduced Heart Rate Variability in Acute Myocardial Infarction

2012

AIM: We investigated the relationships between the autonomic nervous system, as assessed by heart rate variability (HRV) and levels of N-terminal Pro-B-type Natriuretic Peptide (Nt-proBNP) in patients with acute myocardial infarction (MI). METHODS AND RESULTS: The mean of standard deviation of RR intervals (SDNN), the percentage of RR intervals with >50 ms variation (pNN50), square root of mean squared differences of successive RR intervals (rMSSD), and frequency domain parameters (total power (TP), high frequency and low frequency power ratio (LF/HF)) were assessed by 24 h Holter ECG monitoring. 1018 consecutive patients admitted <24 h for an acute MI were included. Plasma Nt-proBNP (Elecs…

MaleAnatomy and PhysiologyEpidemiologyMyocardial Infarctionlcsh:MedicineArrhythmiasCardiovascularCardiovascular SystemHeart RateNatriuretic Peptide BrainPathologyNatriuretic peptideHeart rate variabilityMyocardial infarctionlcsh:Scienceeducation.field_of_studyMultidisciplinaryEjection fractionMiddle AgedQuartileCardiologyMedicineFemaleResearch Articlemedicine.medical_specialtymedicine.drug_classPopulationAutonomic Nervous SystemDiagnostic MedicineInternal medicineHeart ratemedicineHumanscardiovascular diseasesProtein PrecursorseducationBiologyAgedHeart Failurebusiness.industryAcute Cardiovascular Problemslcsh:Rmedicine.diseasePeptide FragmentsBiomarker EpidemiologyAutonomic nervous systemEndocrinologyElectrocardiography Ambulatorylcsh:QbusinessBiomarkersGeneral PathologyPLoS ONE
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